background


Product Information:

OD36 hydrochloride

OD36hydrochloride is a RIPK2 inhibitor with an IC50 of 5.3 nM. OD36 hydrochloride is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 hydrochloride shows ALK2-directed activity with KDs of 37 nM[1][2].

Cat. No.: EX-A15390    Purity: >98%
Chemical
Chemical structure of OD36 hydrochloride


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder


CAS No.2387510-88-3
Purity>98%
FormulaC16H16Cl2N4O2
Mol Weight367.23
 
 
Reference:  

[1]. Justine T Tigno-Aranjuez, et al. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J Biol Chem. 2014 Oct 24;289(43):29651-64.

[2]. Gonzalo Sánchez-Duffhues, et al. Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells. JBMR Plus. 2019 Oct 7;3(11):e10230.

[3]. Tigno-Aranjuez JT, et al. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J Biol Chem. 2014 Oct 24;289(43):29651-64.

CoACoA of OD36 hydrochloride
Smiles:C1COCCOC2=CC(=CC(=C2)C3=C4N=C(N1)C=CN4N=C3)Cl.Cl

KEYWORDS: buy OD36 hydrochloride | OD36 hydrochloride supplier | purchase | cost | manufacturer | order | distributor | buy 2387510-88-3 | 2387510-88-3 supplier